I'm not really all that mysterious

Opioid Induced Hyperalgesia

While the headline mentions the bad news, in truth, this study is hopeful since they were able to restore baseline pain signalling.

CU Boulder study: Narcotic painkillers cause chronic pain • 2016 May 30 • Natalie Munio • The Denver Post

Morphine paradoxically prolongs neuropathic pain in rats by amplifying spinal NLRP3 inflammasome activation • 2016 Apr 19 • Grace et al • PNAS

Using genetic and pharmacological interventions, and innovative Designer Receptor Exclusively Activated by Designer Drugs disruption of microglia reactivity, we demonstrate that opioid-prolonged neuropathic pain arises from spinal microglia and NOD-like receptor protein 3 inflammasome formation/activation. Inhibiting these processes permanently resets amplified pain to basal levels, an effect not previously reported.

Opioid-induced hyperalgesia • Wikipedia

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